Description: Co-Aprovel 300/12.5 mg tablets are a combination medication used primarily for the treatment of high blood pressure (hypertension). The product combines two active ingredients, irbesartan and hydrochlorothiazide, to effectively manage blood pressure levels. Irbesartan is an angiotensin II receptor blocker (ARB) that helps relax blood vessels, while hydrochlorothiazide is a diuretic that helps reduce fluid buildup and lower blood pressure.
Ingredients:
-
Active Ingredients:
- Irbesartan 300 mg
- Hydrochlorothiazide 12.5 mg
-
Other Ingredients:
- Lactose monohydrate
- Microcrystalline cellulose
- Hypromellose
- Magnesium stearate
- Sodium starch glycolate
- Titanium dioxide
- Polyethylene glycol
Usage Instructions:
-
Dosage: The typical dosage is one tablet (300/12.5 mg) taken once daily.
-
Frequency: Once daily, preferably at the same time each day.
-
Special Considerations:
- Can be taken with or without food.
- Swallow the tablet whole; do not crush or chew.
- Dose adjustments may be needed based on individual response and blood pressure levels.
Benefits:
-
Effective Blood Pressure Control: Combines the effects of an ARB and a diuretic to manage high blood pressure more effectively than either component alone.
-
Dual Mechanism: Irbesartan helps relax blood vessels, while hydrochlorothiazide reduces fluid retention, providing comprehensive blood pressure management.
-
Convenient Dosage: Once-daily dosing simplifies adherence to the treatment regimen.
Precautions:
-
Contraindications: Not recommended for individuals with a known hypersensitivity to irbesartan, hydrochlorothiazide, or other sulfonamide-derived drugs. Use with caution in patients with severe kidney or liver impairment.
-
Side Effects: Potential side effects include dizziness, headache, fatigue, and gastrointestinal issues such as nausea or diarrhea. Rare but serious side effects may include electrolyte imbalances or severe allergic reactions.
-
Warnings:
- Monitor kidney function and electrolyte levels regularly, as hydrochlorothiazide can affect these parameters.
- Inform your healthcare provider if you have a history of gout, diabetes, or other cardiovascular conditions.
- Avoid abrupt discontinuation of the medication to prevent sudden increases in blood pressure.
Storage Instructions:
- Store at room temperature, between 15°C and 30°C (59°F and 86°F).
- Keep away from direct sunlight and moisture.
- Keep out of reach of children.
Manufacturer: Sanofi-Aventis
